Altered expression of AXL receptor tyrosine kinase in gastrointestinal cancers: a promising therapeutic target

Gastrointestinal (GI) cancers that include all of the digestive tract organs are generally associated with obesity, lack exercising, smoking, poor diet, and heavy alcohol consumption. Treatment GI typically involves surgery followed by chemotherapy and/or radiation. Unfortunately, intrinsic or acquired resistance to these therapies underscore need for more effective targeted have been proven in other malignancies. The aggressive features share distinct signaling pathways connected each overexpression activation AXL receptor tyrosine kinase. Several preclinical clinical studies involving anti-AXL antibodies small molecule kinase inhibitors test their efficacy solid tumors, including cancers, recently carried out. Therefore, may be a promising therapeutic target overcoming shortcomings standard cancers.